个人简介

刘柳宜，世博娱乐(中国)官方网站 副教授，博士生导师，中山大学逸仙学者计划“新锐学者”。长期致力于分子药物的开发、作用机制解析以及生物医学应用。近五年，以（共）第一作者或（共）通讯作者身份，在J. Am. Chem. Soc.（1篇）、Angew. Chem. Int. Ed.（6篇）、Adv. Sci.（2篇）、Cell Rep.（1篇）等杂志发表系列研究论文，其中，ESI高被引论文1篇。

 

研究方向

（1）分子药物的开发与生物医学应用：致力于新型分子药物开发，解析分子药物对肿瘤微环境的调控机制，并发展抗肿瘤免疫治疗新策略。

（2）核酸二级结构的识别与功能调控：针对特定核酸二级结构的空间构象，发展高选择性化学生物学工具，实现对目标核酸结构的精准识别与功能调控。

 

个人经历

2025.05-至今：世博娱乐(中国)官方网站 ，副教授

2022.09-2025.04：南京大学化学化工世博娱乐 ，博士后 (合作导师：郭子建院士)

2017.09-2022.06：中山大学化学世博娱乐 ，博士 (导师：毛宗万教授)

2013.09-2017.06：中山大学化学世博娱乐 ，学士

 

承担课题

1.    中山大学引进人才计划，2025-2028，主持，在研

2.    国家自然科学基金青年项目，2024-2025，主持，在研

3.    博士后创新人才支持计划，2023-2025，主持，结题

4.    江苏省卓越博士后计划，2023-2025，主持，结题

5.    中国博士后科学基金会面上项目，2023-2025，主持，结题

 

 

论文专著

#为共同第一作者，*为通讯作者

  1. Zeng, Y.-L.; Liu, L.-Y.*; Ma, T.-Z.; Liu, Y.; Liu, B.; Liu, W.; Shen Q.-H.; Wu C.*; Mao, Z.-W.*, Iridium(III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi-Network Synergistic Tumor Immunotherapy.Angew. Chem. Int. Ed. 2024, 63, e202410803. DOI: 10.1002/anie.202410803.
  2. Liu, L.-Y.; Ma, T.-Z.; Zeng, Y.-L.; Liu, W.; Zhang, H.; Mao, Z.-W.* Organic-Platinum Hybrids for Covalent Binding of G-Quadruplexes: Structural Basis and Application to Cancer Immunotherapy. Angew. Chem. Int. Ed.2023, 62, e202305645. DOI: 10.1002/anie.202305645.
  3. Liu, L.-Y.; Ma, T.-Z.; Zeng, Y.-L.; Liu, W.*; Mao, Z.-W.* Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes. J. Am. Chem. Soc.2022, 144, 11878–11887. DOI: 10.1021/jacs.2c04775.
  4. Liu, L.-Y.;Wang, K.-N.; Liu, W.*; Zeng, Y.-L.; Hou, M.-X.; Yang, J.; Mao, Z.-W.* Spatial Matching Selectivity and Solution Structure of Organic-Metal Hybrid to Quadruplex-Duplex Hybrid. Angew. Chem. Int. Ed.2021, 60, 20833 -20839. DOI: 10.1002/anie.202106256.
  5. Liu, L.-Y.#; Liu, W.#; Wang, K.-N.; Zhu, B.-C.; Xia, X.-Y.; Ji, L.-N.; Mao, Z.-W.*Quantitative Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination.Angew. Chem. Int. Ed.2020,59, 9719–9726. DOI: 10.1002/anie.202002422.
  6. Liu, L.-Y.#; Fang, H.#; Chen, Q.#; Chan, M. H.-Y.#; Ng, M.; Wang, K.-N.; Liu, W.; Tian, Z.; Diao, J.*; Mao, Z.-W.*; Yam, V. W.-W.* Multiple-Color Platinum Complex with Super-Large Stokes Shift for Super-Resolution Imaging of Autolysosome Escape.Angew. Chem. Int. Ed. 2020,59 (43), 19229-19236. DOI: 10.1002/anie.202007878.
  7. Chen, Q.# *; Liu, L.-Y.#; Tian, Z.#; Fang, Z.#; Wang, K.-N.; Shao, X.; Zhang, C.; Zou, W.; Rowan, F.; Qiu, K.; Ji, B.; Guan, J.-L.; Li, D. *; Mao, Z.-W.*; Diao, J.* Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature, Cell Rep.2023, 42, 113472. DOI: 10.1016/j.celrep.2023.113472.
  8. Wang, K.-N.#; Liu, L.-Y.#; Mao, D.; Xu, S.; Tan, C.-P.; Cao, Q.; Mao, Z.-W.*; Liu, B.* A Polarity-Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis. Angew. Chem. Int. Ed.2021, 60, 15095-15100. DOI: 10.1002/anie.202104163.
  9. Wang, K.-N.#; Liu, L.-Y.#; Qi, G.; Chao, X.-J.; Ma, W.; Yu, Z.*; Pan, Q.; Mao, Z.-W.*; Liu, B.*; Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation. Adv. Sci.2021, 2004379. DOI: 10.1002/advs.202004379.
  10. Wang, K.-N.#, Shao, X.#; Tian, Z.#; Liu, L.-Y.#; Zhang, C.#; Tan, C.-P.; Zhang, J.; Ling, P.; Liu, F.; Chen, Q.*; Diao, J.*; Mao, Z.-W.* A Continuous Add-On Probe Reveals the Nonlinear Enlargement of Mitochondria in Light-Activated Oncosis. Adv. Sci.2021, 2004566. DOI: 10.1002/advs.202004566.
  11. Hou, M.-X.#; Liu, L.-Y.#; Wang, K.-N.*; Chao, X.-J.; Liu, R.-X.; Mao, Z.-W.*, A molecular rotor sensor for detecting mitochondrial viscosity in apoptotic cells by two-photon fluorescence lifetime imaging. New J. Chem.2020, 44, 11342-11348. DOI: 10.1039/d0nj02108c.
  12. Ma, T.-Z.; Liu, L.-Y.; Zeng, Y.-L.; Ding, K.; Liu, W.; Xiong, X.*; Mao, Z.-W.*, G-quadruplex-guided bifunctional platinum complexes induce multiple pyroptosis pathways for antitumor therapy. Inorg. Chem. Front.2025,12, 707-722. DOI: 10.1039/d4qi02098g.
  13. Ma, T.-Z.; Liu, L.-Y.; Zeng, Y.-L.; Ding, K.; Zhang, H.; Liu, W.*; Cao, Q.; Xia, W.; Xiong, X.*; Wu, C.*; Mao, Z.-W.*, G-quadruplex-guided cisplatin triggers multiple pathways in targeted chemotherapy and immunotherapy. Chem. Sci.2024, 15, 9756-9774. DOI: 10.1039/d4sc00643g.
  14. Li, Y.*; Liu, B.; Zheng, Y.; Hu, M.; Liu, L.-Y.; Li, C.-R.; Zhang, W.*; Lai, Y.-X.*; Mao, Z.-W.*, Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy.J. Med. Chem.2024, 67, 16235-16247. DOI: 10.1021/acs.jmedchem.4c01065
  15. Liu, W.; Zhu, B-C.; Liu, L.-Y.; Xia, X.-Y.; Jang, J.; Dickerhoff, J.; Yang, D.*; Mao, Z.-W.*, Solution structures and effects of a platinum compound successively bound MYC G-quadruplex, Nucleic Acids Res.2024,52, 9397-9406. DOI: 10.1093/nar/gkae649.
  16. Yu, W.; Xu, X.; Liu, L.-Y.; Yang, Y.; Fan, H.*; Li, J.*; Guo，Z., Metal-based interventions in the immune "molecular machinery", Sci. Sin. Chim. 2024, 54, 762-776. DOI: 10.1360/SSC-2023-0256.
  17. Rao, L.-S.; Hao, L.; Liu, L.-Y.; Zeng, Y.-L.; Liang, B.-B.; Liu, W.*; Mao, Z.-W.*, Detection and tracking of cytoplasmic G-quadruplexes in live cells. Chem. Commun.2023, 59, 13348-13351. DOI: 10.1039/d3cc03043a.
  18. Wang, K.-N.; Liu, L. Y.; Mao, D.; Hou, M-X; Tan, C.-P.; Mao, Z.-W.* and Liu B.* A Nuclear Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation. Angew. Chem. Int. Ed.2022, 61, e202114600. DOI: 10.1002/anie.202114600.
  19. Xiong, X.-L.; Liu, L.-Y.; Mao, Z.-W.*; Zou, T.-T.* Approaches towards understanding the mechanism-of-action of metallodrugs. Coordin. Chem. Rev.2022, 453, 214311. DOI: 10.1016/j.ccr.2021.214311.
  20. Zhu, B-C. #; He, J. #; Xia, X.-Y. #; Jiang, J.; Liu, W.*; Liu, L.-Y.; Liang, B.-B.; Yao, H.-G.; Ke, Z.*; Xia, W. *; Mao, Z.-W.* Solution structure of thrombin binding aptamer complex with a non-planar platinum(II) compound. Chem. Sci.2022, 13, 8371-8379. DOI: 10.1039/D2SC01196D.
  21. Ling, Y.-Y. #; Xia, X.-Y. #; Hao, L.; Wang, W.-J.; Zhang, H.; Liu, L.-Y.; Liu, W.; Li, Z.-Y.; Tan, C.-P.*; Mao, Z.-W.* Simultaneous Photoactivation of cGAS-STING Pathway and Pyroptosis by Platinum(II) Triphenylamine Complexes for Cancer Immunotherapy. Angew. Chem. Int. Ed. 2022, 61, e202210988; Angew. Chem. Int. Ed. 2022, 134, e202210988. DOI: 10.1002/anie.202210988.
  22. Zhu, B.-C.; He, J.; Liu, W.*; Xia, X.-Y.; Liu, L.-Y.; Liang, B.-B.; Yao, H.-G.; Liu, B.; Ji, L. N.; Mao, Z.-W.* Selectivity and Targeting of G-Quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics. Angew. Chem. Int. Ed.2021, 60, 15340–15343. DOI:10.1002/anie.202104624.
  23. Wang, K.-N.#; Qi, G.#; Chu, H.#; Chao, X.-J.; Liu, L.-Y.; Li, G.-H.*; Cao, Q.; Mao, Z.-W.*; Liu, B.*, Probing Cell Membrane Damage using Molecular Rotor Probe with Membrane-to-Nucleus Translocation. Mater. Horizons 2020,7, 3226-3233. DOI: 10.1039/D0MH01141J.
  24. Xu, C.-X.; Liu, L.-Y.; Lv, B.; Zhao, H.-Y.; Cao, Q.; Zhai, T.; Mao, Z.-W.*Two novel fan-shaped trinuclear Pt(ii) complexes act as G-quadruplex binders and telomerase inhibitors. Dalton Trans. 2020,49, 9322-9329. DOI: 10.1039/d0dt01767a.
  25. Shao, X.#; Chen, Q.#; Hu, L.#; Tian, Z.; Liu, L.-Y.; Liu, F.; Wang, F.; Ling, P.*; Mao, Z.-W.*; Diao, J.*, Super-resolution quantification of nanoscale damage to mitochondria in live cells. Nano Res. 2020,13, 2149-2155. DOI: 10.1007/s12274-020-2822-9.
  26. Zhao, Z.-J.#; Hou, M.-X.#; Wang, K.-N.*; Liu, L.-Y.; Mao, Z.-W.*Mitochondria-Targeted Iridium III Complex Used as a Two-Photon Phosphorescent Probe for SO2 Derivatives Detection in Vitro and in Vivo.Chin. J. Inorg. Chem. 2020,36, 1113-1122. DOI: 10.11862/CJIC.2020.124.
  27. Wang, K.-N.; Cao, Q.*; Liu, L.-Y.; Zhao, Z.-J.; Liu, W.; Zhou, D.-J.; Tan, C.-P.; Xia, W.; Ji, L.-N.; Mao, Z.-W.* Charge-driven tripod somersault on DNA for ratiometric fluorescence imaging of small molecules in nucleus. Chem. Sci.2019, 10, 10053-10064. DOI: 10.1039/c9sc03594j.
  28. Liu, W.; Zhong, Y.-F.; Liu, L.-Y.; Shen, C.-T.; Zeng, W.; Wang, F.; Yang, D.*; Mao, Z.-W.*Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding.Nat. Commun.2018, 9, 3496. DOI: 10.1038/s41467-018-05810-4.